2022

Hyeogsun Kwon and Ryan C Smith. (2022) Anopheles gambiae actively metabolizes uric acid following Plasmodium infection to limit malaria parasite survival, Front. Physiol, 12, 821869. https://doi.org/10.3389/fphys.2021.821869. IF: 4.37

2021

Hyeogsun Kwon, David R Hall, Ryan C Smith. (2021) Identification of a prostaglandin E2 receptor that regulates mosquito oenocytoid immune cell function in limiting bacteria and parasite infection, Front. Immunol, 12, 680020. https://doi.org/10.3389/fimmu.2021.680020. IF: 8.786

Hyeogsun Kwon, Mubasher Mohammed, Oscar Franzén, Johan Ankarklev, Ryan C Smith. (2021) Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation, eLife, 10:e66192. DOI: 10.7554/eLife.66192. IF: 8.713

Hyeogsun Kwon, Maria L Simões, Rebekah A Reynolds, George Dimopoulos, Ryan C Smith (2021) Additional feeding reveaks differences in immune recognition and growth of Plasmodium parasites in the mosquito host, mSphere, 6(2): e00136-21. https://doi.org/10.1128/mSphere.00136-21. IF: 4.17

Jyothsna Ramesh Kumar, Jessica P. Smith, Hyeogsun Kwon, and Ryan C. Smith (2021) Use of clodronate liposomes to deplete phagocytic immune cells across dipteran species, Front Cell Dev Biol, 9, 627976. https://doi.org/10.3389/fcell.2021.627976. IF: 6.684

2020

Rebekah A Reynolds, Hyeogsun Kwon, Thiago Luiz Alves e Silva, Janet Olivas, Joel Vega-Rodriguez, Ryan C. Smith. (2020) The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor, Sci Rep, 10:21084. https://doi.org/10.1038/s41598-020-78280-8. IF: 4.996

Rebekah A. Reynolds, Hyeogsun Kwon, Ryan C. Smith. (2020) 20-hydroxyecdysone (20E) primes innate immune responses that limit bacteria and malaria parasite survival in Anopheles gambiae, mSphere, 5(2): e00983-19. https://doi.org/10.1128/mSphere.00983-19. IF: 4.17

Hyeogsun Kwon, Yunlong Yang, Sunil Kumar, Dae-Weon Lee, Prati Bajracharya, Travis L. Calkins, Younggyun Kim, Patricia Pietrantonio. (2020) characterization of the first insect prostaglandin (PGE2) receptor: MansePGE2R is expressed in oenocytoids and lipoteichoic acid (LTA) increases transcript expression. Insect Biochem Mol Biol, 117:103290. https://doi.org/10.1016/j.ibmb.2019.103290. IF: 4.714

2019

Hyeogsun Kwon, Ryan C. Smith. (2019) Inhibitors of eicosanoid biosynthesis reveal that multiple lipid signaling pathways influence malaria parasite survival in Anopheles gambiae, Insects, 10(10), 307. https://doi:10.3390/insects10100307. IF: 2.139

Hyeogsun Kwon, Ryan C. Smith. (2019) Chemical depletion of phagocytic immune cells in Anopheles gambiae reveals dual roles of mosquito hemocytes anti-Plasmodium immunity, Proc Natl Acad Sci USA, 116(28): 14119-14128. https://doi.org/10.1073/pnas.1900147116. IF: 12.78

2017

Hyeogsun Kwon, Benjamin R. Arends, and Ryan C. Smith. (2017) Late-phase immune responses limiting oocyst survival are independent of TEP1 function yet display strain specific differences in Anopheles gambiae, Parasit Vectors, 10(1), 369. https://doi.org/10.1186/s13071-017-2308-0. IF: 3.035

2016

Hyeogsun Kwon, Moutaz Ali Agha, Ryan C. Smith, Ronald J. Nachman, Frédéric Marion-Poll, and Patricia V. Pietrantonio. (2016) Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron, Proc Natl Acad Sci USA, 133(25): 6880-6885. doi:10.1073/pnas.1520404113. IF: 12.78

Monika Gulia-Nuss et al., (2016) Genomic insights into the Ixodes scapularis tick vector of Lyme disease, Nat. Commun 7: 10507. doi:10.1038/ncomms10507. IF: 17.69

2013

Hyeogsun Kwon, Patricia V. Pietrantonio. (2013) Calcitonin receptor 1 (AedaeGPCRCAL1) hindgut expression and direct role in myotropic action in females of the mosquito Aedes aegypti (L.). Insect Biochem Mol Biol, 43(7): 588-93. doi:10.1016/j.ibmb.2013.03.005. IF: 4.714

2012

Hyeogsun Kwon, Hsiao-Ling Lu, Michael T. Longnecker, Patricia V. Pietrantonio. (2012) Role in diuresis of a calcitonin receptor (GPRCAL1) expressed in a distal-proximal gradient in renal organs of the mosquito Aedes aegypti (L.), PLoS ONE 7, e50374. http://dx.doi.org/10.1371/journal.pone.0050374. IF: 3.752

2011

Aishwarya Sooresh, Hyeogsun Kwon, Robert Taylor, Patricia Pietrantonio, Michelle Pine and Christie M. Sayes. (2011) Surface functionalization of silver nanoparticles: novel applications for insect vector control, ACS applied Materials & interfaces. 3(10):3779-87, DOI: 10.1021/am201167v. IF: 10.38

2007

Hyeogsun Kwon, David W. Stanley and Jon S. Miller (2007) Bacterial challenge and eicosanoids act in plasmatocyte spreading, Entomol Exp Appl, 124: 285-292. DOI: 10.1111/j.1570-7458.2007.00582.x. IF: 1.99

2005

Richard O. Musser, Hyeogsun Kwon, Spencer A. Williams, C. James White, Michael A. Romano, Scott M. Holt, Shay Bradbury, Judith K. Brown, and Gary W. Felton. (2005) Evidence that caterpillar labial saliva suppresses infectivity of potential bacterial pathogen, Arch Insect Biochem Physiol 58: 138-144. DOI: 10.1002/arch.20031. IF: 1.70

Google scholar

ResearchGate

Highlights

Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation

Identification of a prostaglandin E2 receptor that regulates mosquito oenocytoid immune cell function in limiting bacteria and parasite infection

Chemical depletion of phagocytic immune cells in Anopheles gambiae reveals dual roles of mosquito hemocytes anti-Plasmodium immunity

Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron

Role in diuresis of a calcitonin receptor (GPRCAL1) expressed in a distal-proximal gradient in renal organs of the mosquito Aedes aegypti (L.)

Publications

2023

Hannah J. Loghry, Hyeogsun Kwon , Ryan C Smith, Noelle A Sondjaja, Sarah J Minkler, Sophie Young, Nicolas J Wheeler, Mostafa Zamanian, Lyric C Bartholomay, Michael J Kimber. (2022) Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host. Sci. Rep, 13 (1), 8778 https://doi.org/10.1038/s41598-023-35940-9 IF: 3.9

2024

George-Rafael Samantsidis, Hyeogsun Kwon, Megan Wendland, Catherine Fonder, Ryan C Smith. (2024) TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae. bioRxiv, doi: 10.1101/2024.05.02.592209

David R Hall, Rebecca M Johnson, Hyeogsun Kwon, Zannatul Ferdous, S Viridiana Laredo-Tiscareño, Bradley J Blitvich, Doug E Brackney, Ryan C Smith (2024) Mosquito immune cells enhance dengue and Zika virus dissemination in Aedes aegypti. bioRxiv, doi: 10.1101/2024.04.03.587950

Enzo Mameli, George-Rafael Samantsidis, Raghuvir Viswanatha, Hyeogsun Kwon , David R. Hall, Matthew Butnaru, Yanhui Hu, Stephanie E. Mohr, Norbert Perrimon , Ryan C. Smith.(2024) A genome-wide CRISPR screen in Anopheles mosquito cells identifies essential genes and required components of clodronate liposome function. bioRxiv, doi: https://doi.org/10.1101/2024.09.24.614595

2025

Hyeogsun Kwon and Ryan C. Smith. (2025) Protocol to chemically deplete phagocytic hemocytes in Anopheles gambiae using clodronate liposomes. STAR Protocols 6, 103819, doi: https://doi.org/10.1016/j.xpro.2025.103819 IF:1.3

Olivia Goldman et al. (2025) Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito. bioRxiv, https://doi.org/10.1101/2025.02.25.639765

Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti

David R. Hall, Rebecca M. Johnson, Hyeogsun Kwon, Zannatul Ferdous, S. Viridiana Laredo-Tiscareño, Bradley J. Blitvich, Doug E. Brackney and Ryan C. Smith. (2025) Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti. Nat. Commun 16 5891, https://doi.org/10.1038/s41467-025-61139-9 IF: 14.7

George-Rafael Samantsidis, Hyeogsun Kwon, Megan Wendland, Catherine Fonder, Ryan C Smith. (2025) TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae. PLoS Pathog, https://doi.org/10.1371/journal.ppat.1013329 IF:5.5